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Magali Michaud Selected Research

olesoxime

12/2015Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
9/2014Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.
8/2008Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy.
8/2007Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.

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Magali Michaud Research Topics

Disease

3Neurodegenerative Diseases (Neurodegenerative Disease)
12/2015 - 08/2007
2Myocardial Infarction
06/2015 - 02/2014
2Ischemia
06/2015 - 02/2014
2Infarction (Infarctions)
06/2015 - 02/2014
1Necrosis
01/2018
1Pancreatitis
01/2018
1Mitochondrial Diseases (Mitochondrial Disease)
12/2015
1Cerebral Cortical Thinning
12/2015
1Huntington Disease (Huntington's Disease)
12/2015
1Fatty Liver
06/2015
1Hepatitis
06/2015
1Parkinsonian Disorders (Parkinsonism)
09/2014
1Reperfusion Injury
02/2014
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
04/2010
1Respiratory Insufficiency (Respiratory Failure)
04/2010
1Paralysis (Palsy)
04/2010
1Neoplasms (Cancer)
08/2008
1Hyperalgesia
08/2008
1Peripheral Nervous System Diseases (PNS Diseases)
08/2008
1Pain (Aches)
08/2008
1Painful Neuropathy
08/2008
1Neuralgia (Stump Neuralgia)
08/2008
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
08/2007

Drug/Important Bio-Agent (IBA)

43,5-seco-4-norcholestan-5-one oxime-3-olIBA
01/2018 - 02/2014
4olesoximeIBA
12/2015 - 08/2007
3Mitochondrial Permeability Transition PoreIBA
01/2018 - 02/2014
3Proteins (Proteins, Gene)FDA Link
12/2015 - 04/2010
2CholesterolIBA
09/2014 - 08/2008
2Pharmaceutical PreparationsIBA
02/2014 - 08/2007
1palmitoleic acidIBA
01/2018
1EstersIBA
01/2018
1Fatty Acids (Saturated Fatty Acids)IBA
01/2018
1Huntingtin ProteinIBA
12/2015
1CalpainIBA
12/2015
1CalciumIBA
12/2015
1Peptide Hydrolases (Proteases)FDA Link
12/2015
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
06/2015
1PalmitatesIBA
06/2015
1alpha-SynucleinIBA
09/2014
1OximesIBA
09/2014
1Formaldehyde (Formol)FDA Link
08/2008
1Streptozocin (Streptozotocin)FDA Link
08/2008
1Vincristine (Oncovin)FDA LinkGeneric
08/2008
1Analgesics (Analgesic Drugs)IBA
08/2008

Therapy/Procedure

2Therapeutics
06/2015 - 08/2008
1Drug Therapy (Chemotherapy)
08/2008
1Oral Administration
08/2008